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Eur Cells Mater 23:170181 Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH et al (2014) Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice

In vitro experiments demonstrated that quercetin treatment led to decreased expression of TGF-1, -SMA, HMGB1, TLR2/TLR4, and NF-B p65 proteins in COL11 mRNA, suggesting that quercetin may inhibit HSCs activation and improve liver fibrosis by modulating the HMGB1/TLR/NF-B signaling pathway

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